We herein report a multiple warty dyskeratoma in a female patient. Table 1 practice points c scale as compared to nongenital lesions. Warty dyskeratoma, he 20x 4701 warty dyskeratoma, he 20x 4702. Warty dyskeratoma wd is regarded as a benign follicular adnexal neoplasm. Warty dyskeratoma is an uncommon entity usually characterized by a single solitary papule or nodule on the head or neck with a comedolike plug. Based on its regular association with pilosebaceous units, it has been suggested that wd is a true benign follicular adnexal neoplasm kaddu et al. Subsequently, warty dyskeratoma has also been reported to occur on oral and vulvar mucosa. Warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middleaged or older persons. It is characterized by solitary papule or nodule arising from the scalp, face or neck in middleaged persons or elderly. It was called warty dyskeratoma by szymanski in 1957. The central depression is filled with a plug of keratinous material containing some grains. In this case, histopathology proved to be valuable in confirming the diagnosis. Multiple warty dyskeratoma is an extremely rare variant. It usually develops in the head and neck region as a.
This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. The papule shows a cupshaped, keratinfilled invagination. At its base are elongated dermal papillae arranged as villous processes. Self assessment test handout poznan, december 1 3, 2016. The diagnostic related groups drgs are a patient classification scheme which provides a means of relating the type of patients a hospital treats. Multiple follicles, warty dyskeratoma introduction graham and helwig1 first described warty dyskeratoma wd as isolated dariers disease in 1954 and this malady was more properly called warty dyskeratoma by szymanski2 in 1957. C vulvar lichen simplex chronicus may show less hyperplasia and minisymposium. The profound dyskeratotic changes may mimic invasive squamous cell carcinoma. A case of warty dyskeratoma on an unusual location ncbi.
Warty dyskeratoma definition of warty dyskeratoma by. Dyskeratoma definition of dyskeratoma by medical dictionary. Graham and helwig addressed warty dyskeratoma as iso lated dariers disease or. Blisters, whose contents are cytoplasm and infiltrating cells, are divided into intraepidermal and subepidermal, according to the histological findings fig. From the division of oral and maxillofacial pathology, columbia. Trichilemmomas are benign follicular neoplasms that exhibit differentiation toward the outer root sheath of the pilosebaceous follicular epithelium. Warty dyskeratoma wd, also known as isolated darier disease or focal acantholytic dyskeratosis,1 is a rare mucocutaneous lesion.
Warty dyskeratoma is a tiny, nodular lesion with a characteristic histologic picture that resembles that of dariers disease. Pdf warty dyskeratoma wd is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middleaged or. Warty dyskeratoma isolated dyskeratosis follicularis. Warty dyskeratoma definition of warty dyskeratoma at. Wd is a rare tumor that is characterized by a solitary papule or nodule that is most.
It usually develops in the head and neck region as a nodular lesion with a central keratotic plug. Warty dyskeratoma, also known as an isolated dyskeratosis follicularis. Dermatopathology reference describes warty dyskeratoma histopathology including histologic features and provides links to additional medical references. Warty dyskeratoma of the leg jama dermatology jama network.
Ko, md key facts clinical issues solitary very rarely multiple umbilicated papule or nodule often on head or neck microscopic pathology cupshaped lesion sometimes associated with hair follicles hyperkeratosis and parakeratosis suprabasilar acantholysis with villi at base mixed inflammatory infiltrate in dermis corp ronds round to slightly oval nucleus with. Jan 06, 2019 the cause of warty dyskeratoma is unknown, and hence, currently there are no known methods to prevent the tumor occurrence. A 49yearold white man developed focal oral warty dyskeratoma, which is a solitary, elevated nodule with a keratotic umbilicated center. Histopathology of the excised nodule revealed a large cupshaped. On histopathology, warty dyskeratoma is a well circumscribed endo and exophytic cupshaped lesion.
There is hyperkeratosis and parakeratosis above central acantholytic dyskeratosis with villi at the base. The most common clinical presentation is a welldefined nodule or papule located on the head or neck of adults. When it occurs in the oral cavity, wd is most commonly seen on the hard palate. Histology of warty dyskeratoma is identical to keratotic pap ules of dariers disease. Soepronos textbook is available on and includes detailed information on over 600 entities and includes four dvd diskettes with highresolution images that provide a virtual dermatopathology reference and guide. The cause of warty dyskeratoma is unknown, and hence, currently there are no known methods to prevent the tumor occurrence. Oral warty dyskeratoma of the retromolar trigone jaad case reports. The histopathologic differential diagnoses of warty dyskeratoma include.
We report a 62yearold chinese male presented with a. C warty dyskeratomaa vasculopathic pattern c zoons vulvitis c behcets disease a discussed in differential diagnoses. Warty dyskeratoma definition at, a free online dictionary with pronunciation, synonyms and translation. Plaquetype warty dyskeratoma of the scalp with multiple follicular involvements case report a 47yearold woman presented with an asymptomatic brown. Warty dyskeratoma bioinformatics tool laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on cocitations. Warty dyskeratoma as a cutaneous horn of the mons pubis. Warty dyskeratoma wd is a rare tumor that presents mainly as an isolated papule or nodule on the scalp, face or neck. Please visit the project page for details or ask questions at wikipedia talk.
According to some authors, majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm. Pdf an unusual location of subungual warty dyskeratoma. To our knowledge, there have been only 8 cases reported in english. Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. Kaddu s, dong h, mayer g, kerl h, cerroni l 2002 warty dyskeratoma follicular dyskeratoma.
Histologically, it shows a cupshaped keratinfilled invagination of an acanthotic epidermis, suprabasilar clefting with villi projecting into the. An unusually large warty dyskeratoma on a previously unreported site in a young male with relevant histological and histochemical studies is presented. When dealing with focal acantholytic dyskeratosis several differential. The lesions in comedonal dariers disease have the histological features of warty dyskeratoma. Because it often arises in association with a dilated hair follicle, it has been postulated to have a follicular origin. Helwig, in 1954 first described a solitary lesion and called it as isolated darier disease. Warty dyskeratomas are scaly nodules with a central keratotic plug that can also resemble squamous cell cancer so they are usually biopsied. It usually presents as a solitary, asymptomatic umbilicated papule, most often in the head and neck region of middle to olderage adults. Warty dyskeratoma features an umbilicated papule, usually on the face, head, or neck, that is associated with a follicular unit. Lesions are generally solitary but grouped verrucous papules on the scalp.
Intraepidermal blisters are classified by formation mechanism into severe spongiosis. Additional and relevant useful information for warty dyskeratoma. Until now, these changes have been described only on the skin and the mucosa of the oral cavity. On histology, features of dariers disease can be seen but the clinical picture differentiates warty dyskeratoma as it is a solitary nodule and not multiple crusted papules as seen in dariers disease. There is suprabasilar acantholysis with dyskeratotic.
Plaquetype warty dyskeratoma of the scalp with multiple. Corps ronds and corps grainswarty dyskeratoma juniper. Wd is rare and has a predilection for the face, scalp, and neck. Dariers disease, grovers disease, haileyhailey disease. Isolated lesions with histologic features almost indistinguishable from those in darier disease were first given special standing by helwig. Jan 23, 2017 warty dyskeratoma wd is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. Warty dyskeratoma wd is a benign endophytic cutaneous lesion, characterized by proliferation of squamous epithelium, acantholysis, and dyskeratosis weedon et al. The code is valid for the year 2020 for the submission of hipaacovered transactions. Warty dyskeratomafocal acantholytic dyskeratosis wiley online.
Dermoscopy of multiple warty dyskeratomas dermatology. A histopathologic diagnosis of subungual warty dyskeratoma was made. Significantly revised and updated content throughout this edition brings you the latest information on the etiology, clinical features, histopathology, treatment, and prognosis of each disease entity, as well as cuttingedge. Outcomesresolutions the prognosis of warty dyskeratoma is excellent on its surgical removal, in most cases. Warty dyskeratoma wd is a rare cutaneous lesion histopathologically characterized by acantholytic dyskeratosis. The histopathology shows a pattern of acantholytic dyskeratosis. Graham and helwig first described warty dyskeratoma as isolated dariers disease in 1954. An unusual location of subungual warty dyskeratoma. When it occurs in the oral cavity, wd is most commonly seen on the. Warty dyskeratoma wd is a benign solitary lesion of unknown aetiology affecting the skin and oral mucosa.
Josef feit, hana jedlickova, gunter burg, ludek matyska, spasoje radovanovic et al. Warty dyskeratoma frequently arises as a single lesion with a central keratotic plug on the skin of middleaged or elderly people. David weedon ao md frcpa fcaphon, in weedons skin pathology third edition, 2010. Warty dyskeratoma wd, also known as isolated follicular dyskeratosis, is relatively uncommon benign epidermal proliferation first reported by szymanski in 19571. Warty dyskeratoma is a solitary lesion of unknown etiology that has microscopic resemblence to dariers disease.
Plaque form of warty dyskeratoma acantholytic dyskeratotic acanthoma plaque form of warty dyskeratoma acantholytic dyskeratotic acanthoma omulecki, anastazy. Although trichilemmomas typically are isolated, patients. Warty dyskeratomas follicular dyskeratomas are rare, usually solitary, papules or nodules with an umbilicated or porelike center. Wd presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face. We report a 32yearold man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. Correspondence plaquetype warty dyskeratoma of the scalp with multiple follicular involvements case report a 47yearold woman presented with an asymptomatic brown. Epithelial proliferation of benign squamous cells surrounds a keratinfilled center or parakeratotic plug figure 1. The aetiology of warty dyskeratoma remains elusive. To our knowledge, our case includes the first description of this lesion on the vocal cord.
We report a 32yearold man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first. This article is within the scope of wikiproject medicine, which recommends that medicinerelated articles follow the manual of style for medicinerelated articles and that biomedical information in any article use highquality medical sources. Wd presents as a whitish or grayish solitary papule or small nodules with a keratotic plug, usually limited to the head and neck of middleaged patients. There is a circumscribed, cupshaped, invaginating lesion extending into the underlying dermis. Warty dyskeratoma involving two adjoining follicles. Pdf warty dyskeratoma involving two adjoining follicles. Soeprono teaches and practices dermatopathology at loma linda university, school of medicine, department of dermatology. A 61yearold woman presented with a 1year history of an asymptomatic, progressively growing nodule on the mons pubis.
Lowpower architecture this is a lowpower view of a warty dyskeratoma, a cupshaped lesion. Warty dyskeratoma incorrect because warty dyskeratoma is sporadic, acquired, and unilesional form of dariers disease with acanthotic epidermis, suprabasal acantholysis and dyskeratotic grains and corps ronds at the base of follicular keratin plug. Warty dyskeratoma a rare, usually solitary, benign epithelial tumor of the skin that appears to arise from a hair follicle. The term focal oral warty dyskeratoma was suggested to. Journal of the american academy of dermatology 473. For more information on how to use laverne, please read the how to guide.